Uridine Supplement: A Powerhouse for Synaptic Plasticity

Uridine to improve cognition and synaptic plasticityUridine is a choline related supplement with key benefits that may improve overall cognition, slow down an aging brain, improve memory, focus, alertness and increase mood.

What is Uridine?

Better memory formation, learning capacity, increased mood and the ability to potentially strengthen the synapses where the brain is able to form new connections are the key benefits associated with Uridine Nootropics.

Uridine is one of the five standard nucleosides and is part of RNA (ribonucleic acid) which is just as vital as DNA. We produce it in the liver and it plays an important role in regulating enzymes in the brain and the fusion of phosphatidylcholine.

It is found in high concentrations of beer, sugar, tomatoes and broccoli however, low levels of uridine in the brain may decrease the activity of the synapses and weaken them. This may cause problems with memory and cognition.

Uridine supplements are thought to improve cognition and work well in cooperation with choline sources or fish oils which will increase brain health.

How does Uridine Work?

The main function of Uridine is thought to increase synaptic plasticity (strength or weakness of synapses) and synthesis of phosphatidylcholine or PC.

PC is a chemical that plays a roll in signaling cells and activating enzymes. It is thought to be a component of slowing down the process of age related cognitive decline and improving both brain function and memory capacity.

Uridine increases the production of neuronal processes (neurites) that come from the body of a neuron. They connect to other neurons to form synapses in other areas of the brain which increase memory formation and creation of new memories.

Synaptogenesis which is the forming of synapses is thought to increase when Uridine is available to the brain. This may lead to improved cognitive function.

Uridine, is also thought to increase Dopamine levels in the brain. This is a neurotransmitter that sends signals to other nerve cells and plays a major role in motivation, mood and pleasure.

Low levels of Dopamine are thought to be the cause for many diseases of the nervous system including Parkinson’s disease, restless leg syndrome and ADHD which are all associated with decreased dopamine activity.

Also, the increased synthesis of phosphatidylcholine helps to form Acetylcholine. This is another neurotransmitter that plays a roll in attention, thought process, memory and motivation.

Benefits of Uridine

Uridine supplements may have many cognitive benefits. These include potentially slowing down the aging brain, improving memory and sharpening cognitive functions including focus and alertness, which may come from the increase in Acetylcholine in the brain.

It is also thought to fight depression, improve mood and motivation which may be the result of the increase in Dopamine. This may help reduce anxiety, stress levels and even symptoms of OCD.

Also, it may improve brain cell health. Uridine is associated with improvement/prevention of symptoms of Alzheimer’s. The improvement in synaptic connections may be directly linked. More research needs to be done.

Finally, Uridine effects work best when taking with choline. Some high quality choline supplements include Alpha GPC and CDP choline.

Why Take Uridine? It promotes;

  • Improved cognition
  • Synaptic plasticity
  • Improved mood

Side Effects of Uridine

Uridine is considered a very safe supplement and appears to be well tolerated. It is already found in minimal amounts in certain foods and produced in our body.

Staying within the recommended dosage should not cause any side effects however some have been reported including;

  • Fatigue
  • Headaches
  • Gas

Also, Uridine has been associated with lowering levels of vitamin B12. Taking a multivitamin is suggested to compensate.

How to take Uridine?

Uridine can be taken alone or with other Nootropics including choline supplements which may enhance it’s effects. Some high choline sources are Alpha GPC and CDP choline. Also Uridine can be taken with Centrophenoxine, which is similar to choline, to enhance the effects on memory and mental performance.

It is suggested to take it with food. The recommended dosage is between 500mg-1000mg however dosages of up to 1 gram have been used for Nootropic effects.






2017-09-08T23:27:41+00:00 Cholines|