3,3′ Diindolylmethane also called DIM, is promoted to have key benefits in balancing hormones in both men and women, may reduce inflammation and joint pain, alleviate symptoms of PMS and have many other health benefits.
What is Diindolylmethane?
Diindolylmethane (DIM) is used to improve a multitude of different health issues since it has shown varied medicinal effects.
DIM is a partial effect of the digestion of a natural substance called indole-3-carbinol (I3C) which is found in the Brassica family of vegetables including broccoli, kale, brussels sprouts, cauliflower and others. When indole-3-carbinol is broken down by enzymes in the stomach, it creates Diindolylmethane.
Supplementation of Diindolylmethane is mainly used for it’s potential in aiding in the healthy balancing of hormonal activity in both men and women.
It is also being currently researched for it’s potential effects on preventing the development and growth of certain cancers and has shown promising effects on breast, colorectal and uterine cancers. The FDA does not approve DIM supplementation for this purpose and more research is required to determine it’s effectiveness.
DIM is also thought to have anti-inflammatory, antibacterial, anti-angiogenesis and anti-viral effects.
DIM contains powerful phytonutrients (plant nutrients) that are believed to create healthy hormonal balances in men and women by regulating estrogen levels in the body.
Diindolylmethane (DIM) is suggested to work on drastic increases or decreases of estrogen levels (estrogen dominance) and estrogen metabolism.
It is thought to reduce the level of 16-hydroxy estrogen (bad estrogen) and increase the creation of higher levels of 2-hydroxy estrogen (good estrogen). This encourages unmetabolized, bad estrogen to turn into good estrogen.
When estrogen is broken down in the body, it creates either good or bad metabolites. Good or valuable metabolites act as anti-oxidants and protect the heart and brain from excessive damaging free radicals that naturally increase with age and can potentially cause diseases.
DIM also may be beneficial for people suffering from arthritis. It seems to have anti-inflammatory properties that help to reduce arthritic pain.
It is believed to effectively decrease inflammatory cytokine expression in animal tests and block inflammatory enzymes which may reduce inflammation and provide relief from pain. However, there is no evidence that suggest it can prevent arthritis.
Benefits of Diindolylmethane (DIM) For Men
Estrogen is present in both males and females. In men, testosterone is transformed into estrogen and men produce higher levels of estrogen in the later stages of life.
DIM, is thought to act as an aromatase inhibitor. This an enzyme that is responsible for the conversion of testosterone into estrogen. DIM is believed to restrain this activity and defend testosterone levels from being depleted.
The increase of testosterone is important in lowering the risk of cardiovascular disease and conditions. Low levels of testosterone can create lack of energy, erectile dysfunction, loss of muscle mass and low sex drive. Other symptoms can be hair loss and an increase in body fat that can effect overall physical performance.
If there is too much estrogen, it can can cause heart disease, prostate cancer and gynecomastia (enlarged breasts in men). DIM is thought to reduce symptoms of excessive breast tissue by potentially reducing estrogen dominance and increasing testosterone. DIM seems to create a hormone balance between them, which may also lead to many other benefits for men.
Also, a proper balance may also help the efficiency of cholesterol synthesis in the liver which may help to eliminate cholesterol from the body.
Men have a greater risk for heart attacks, strokes and disease that may be caused by high cholesterol than women do, even though statistically there is a greater number of women with high cholesterol than men.
These supplements are also used as testosterone boosters. They may be a potential alternative to testosterone therapies since they may have less side effects that are commonly associated with these therapies.
Benefits of Diindolylmethane (DIM) For Women
For women, DIM is believed to balance estrogen and progesterone levels which may create a healthier balance in hormones. An imbalance in these hormones is the most common problem in women over the age of 35.
Women produce estrogen, progesterone and testosterone in the ovaries and adrenal glands. Naturally as women age, levels of progesterone and testosterone decline which leaves an excess of estrogen.
On the flip side, after menopause, childbirth or when a woman stops menstruating, the production of estrogen decreases which can cause hot flashes, vaginal dryness and low sex drive.
When estrogen levels are imbalanced, deficient or dominating (Estrogen Dominance) it creates a hormone imbalance which can cause weight gain, bloating, water retention, mood swings, depression, decreased sexual drive, diseases and other health issues.
Estrogen dominance can occur from birth control pills, use of hormone replacements, poor diet, smoking, alcohol use and stress which is associated with the adrenal gland, just to name a few.
Also, too much estrogen can possibly cause reoccurring bronchitis, severe allergies and asthma, heightened symptoms of menopause, severe PMS, headaches, irritability and infertility.
Estrogen is present in every organ in the body and utilized for many purposes. When there are higher levels of excessive bad estrogen, it stores in fat cells and it is difficult for the body to detoxify. If it remains there for excessive periods of time, it can cause risk for diseases, especially hormone related forms of cancer.
DIM supplementation is taken by women to balance hormones and are thought to improve symptoms of menopause, PMS, hormonal acne and may even support weight loss. It also may be a preventative, reducing the risk of potential health issues and certain cancers that are related to estrogen imbalances.
Diindolylmethane (DIM) Side Effects & Dosage
Diindolylmethane is generally considered likely safe when taken for a short period of time (12 weeks) in small dosages. Cycling DIM is recommended after this period of time and you should wait approximately 12 weeks off of DIM before taking it again.
It is important to follow the recommended dosage on the bottle. The average dosage of DIM is approximately 100mg-300mg per day however dosages of 30mg-100mg per day may be sufficient and effective according to some studies.
Through the average dietary consumption of brassica vegetables such as broccoli, cauliflower and kale, we get approximately 2mg-20mg of DIM daily. However, you would have to eat close to 2 pounds of these veggies per day to get the full DIM potential effects.
DIM can possibly be unsafe if it is used over a long period of time and when taken in high dosages. These cases were said to be caused by dosages higher than 600mg a day and is NOT considered safe. Dosages of over and in some cases under 300mg per day may cause headaches and upset stomach.
There is not a full understanding of DIM’s effects on estrogen and it may interact with estrogen based medications, so it is best to avoid it if taking these.
DIM may also lower sodium levels and it is not recommended for people taking diuretics which also lower sodium levels in the body. In rare cases, this combination may cause the development of hyponatremia.
Finally, DIM is not recommended for pregnant or breast feeding women, people with hormone sensitive disorders, or people with cancer.
It may take some time to experience the effects of DIM in some cases. Some people have immediate results while others state that it takes a few weeks to experience the benefits.
These are just guidelines. Please speak to your doctor first before taking DIM to determine whether this supplement is right for you.
Diindolylmethane (DIM) is a plant based metabolic compound that comes from certain group of vegetables with key benefits in potentially reducing high levels of estrogen and balancing hormones in both women and men who may have this health problem.
High levels of estrogen in women can cause mood swings, painful and severe symptoms of PMS, menopause, irregular menstrual cycles, lack of energy, hormonal acne, weight gain and many other health problems.
In men, DIM may inhibit the depletion of testosterone levels and may improve physical performance, muscle mass, sex drive, energy levels and more.
Users online have reported that this supplement provides relief from many of these problems that are due to hormone imbalances.
DIM is viewed as generally safe when taken in small dosages for short periods of time (12 week cycles).